Drug Effectiveness
Neuro-Immune Axis MPS
Assay
- Microgliosis live cell imaging
- Live cell assessment for phagocytosis
- Neuroinflammation and neurodegeneration assessment
- Amyloid beta or alpha synuclein production assessment
Publication List
- J. Park, I. Wetzel, I. Marriott, D. Dréau, C. D’Avanzo, D.Y. Kim, R.E. Tanzi, H. Cho, “A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease,” Nature Neuroscience 2018, 21:941-951
- H. Chun, I. Marriott, C.J. Lee, H. Cho, “Elucidating the Interactive Roles of Glia in Alzheimer’s Disease Using Established and Newly Developed Experimental Models,” Frontiers in Neurology 2018, 9:797
- A. McQuade, Y.J. Kang, J. Hasselmann, A. Jairaman, A. Sotelo, S.K. Shabestari, M. Coburn, J.P. Chadarevian, G. Fote, C.H. Tu, E. Danhash, J. Silva, E. Martinez, C. Cotman, G.A. Prieto, L.M. Thompson, J.S. Steffan, I. Smith, H. Davtyan, M. Cahalan, H. Cho, M. Blurton-Jones, “Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease,” Nature Communications 2020, 11:5320
H. Chun, H. Im, Y.J. Kang, Y. Kim, J.H. Shin, W. Won, J. Lim, Y. Ju, Y.M. Park, S. Kim, S.E. Lee, J. Lee, J. Woo, Y. Hwang, H. Cho, S. Jo, J.-H. Park, D. Kim, D.Y. Kim, J.-S. Seo, B.J. Gwag, Y.S. Kim, K.D. Park, B.-K. Kaang, H. Cho, H. Ryu*, C.J. Lee*, “Severe reactive astrocytes precipitate the hallmarks of Alzheimer’s disease via H2O2,” Nature Neuroscience 2020, 23:9
Y.J. Kang, H.-Y. Tan, C.Y. Lee, H. Cho “An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models,” Advanced Science 2021, 8:2101251 (frontispiece cover imaged)
V.A. Jairaman, A. McQuade, A. Granzotto, Y.J. Kang, J.P. Chadarevian, S. Gandhi, I. Parker, I. Smith, H. Cho, S.L. Sensi, S. Othy, M. Blurton-Jones, M.D. Cahalan “TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia,” eLife 2022, 11:e73021
Y.J. Kang, Y.N. Diep, M. Tran, V.T.A Tran, G. Ambrin, H. Ngo, H. Cho*, “Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration,” Nature Protocols 2023, 18:9 (cover imaged)
Y.J. Kang, S.J. Hyeon, A. McQuade, J. Lim, S.H. Baek, Y.N. Diep, K.V. Do, Y Jeon, D.-G. Jo, C.J. Lee, M. Blurton-Jones, H. Ryu, H. Cho, “Neurotoxic microglial activation via IFNγ-induced Nrf2 reduction exacerbating Alzheimer’s disease,” Advanced Sciences, 2024, 12:2304357
J.-C. Park, J.W. Han, W. Lee, J. Kim, S.-E. Lee, D. Lee, H. Choi, J. Han, Y.J. Kang, Y.N. Diep, H. Cho, J.-I. Kim, I. Mook-Jung, “Microglia gravitate toward amyloid plaques surrounded by externalized phosphatidylserine via TREM2,” Advanced Science, 2024, 11:2400064
X. Zhu, Y.N. Diep, V.T.A. Tran, Y.J. Kang, L.P. Lee, H. Cho, “Piezo1 activation promotes glial anti-inflammation and tau dephosphorylation in an Alzheimer’s disease model,” BioChip 2025, 19: https://doi.org/10.1007/s13206 025-00228-9
