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PIPELINE

NeuroLynx provides the best platforms for drugs in neurological disorders.

> Drug Penetration

- BBB Chip

  • Brain functions
    • Blood-Brain barrier
  • Application
    • Neurovascular dementia
    • Drug penetration across BBB
  • Availability
    • Available


- BCB Chip

  • Brain functions
    • Blood-Choroid barrier
    • Neurovascular unit
  • Application
    • Alzheimer's dementia
    • Parkinson's dementia
  • Availability
    • Under develop


> Drug Penetration

- Neuroglia Chip

  • Brain functions
    • Neuron-Glial interactions
  • Application
    • Neuroinflammation
    • Alzheimer's dementia
    • Parkinson's dementia
  • Availability
    • Available


- Neuronal Circuitory Chip

  • Brain functions
    • Neuron-Neuron interactions
  • Application
    • Disease propagation
  • Availability
    • Available

> Assay

Pipeline

NeuroLynx Pipeline

Target

Model

Brain Functions

Applications

Availability

Drug

Penetration

BBB Chip

Blood-Brain barrier

Neurovascular dementia

Drug penetration across BBB

Available

BCB Chip

Blood-Choroid barrier

Neurovascular unit

Alzheimer's dementia

Parkinson's dementia

Under 

develop

Drug

Penetration

Neuroglia Chip

Neuron-Glial interactions

Neuroinflammation

Alzheimer's dementia

Parkinson's dementia

Available

Neural Circuitory 

Chip

Neuron-Neuron interactions

Disease propagation

Available

Drug Penetration

Investigate Drug Delivery to Brain

BBB Chip

Blood-Brain barrier-on-Chip

Mechanism

BBB chip reconstruct blood-brain barrier with human brain endothelial cell from human embryonic stem cell.


Key features

- Drug infiltration by time

- Drug affect in blood brain barrier

- Inflammation in blood brain barrier


Assay

Tight junction expression

Drug penetration

BCB Chip

Blood-Choroid barrier-on-Chip

Mechanism

BCB Chip reconstruct blood choroid barrier with human embryonic stem cell derive choroid epithelial cell


Key features

- Drug infiltration by time

- Drug affect in blood choroid barrier

- Drug effect in choroid-neurodegeneration


Drug Effectiveness

Investigate Drug Effect

in Brain

Neuroglia Chip

Neuron-Glial Interaction

Mechanism

MG Chip reconstruct neuron-glial interaction with human neuronal cells


Key features

- Recapitulate early / late Alzheimer's dementia

- Recapitulate Parkinson's dementia

- Investigate gliosis by time


Assay

Neuronal Circuit Chip

Neuron-Neuron Interaction

Mechanism

Neuronal Chip reconstruct neuronal interaction with human neuron


Key features

- Recapitulate neuronal propagation of tau

- Drug effect in neuronal propagation


Assay