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Pipeline

Target

Model

Brain Functions

Applications

BBB Chip

Blood-Brain barrier

Neurovascular dementia

Drug penetration across BBB

BCB Chip

Blood-Choroid barrier

Choroid plexus

Neuron-Glia Chip

Neuron-Glial interactions

Neuroinflammation

Alzheimer's dementia

Parkinson's dementia

Neural Circuitory 

Chip

Neuron-Neuron interactions

Disease propagation

Gut-Brain-Vascular

 Axis

Gut-Brain interaction via blood vessel

Neuroinflammation

Dysbiosis

Probiotics

Gut-Nerve-Brain 

Axis

Gut-Brain interaction via vagus nerve

Neuroinflammation

Dysbiosis

Probiotics

Drug Penetration

BBB Chip

  Assay


  • Drug penetration live cell image
  • Barrier tightness
  • Brain endothelial cell activation

 Publication List


  1. H. Cho, J.H. Seo, K.H.K. Wong, Y. Terasaki, J. Park, K. Bong, K. Arai, E.H. Lo, D. Irimia, “Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology,” Scientific Reports 2015, 5:15222
  2. Y. Xue, M. Tran, S. Shin, J. Lee, H. Cho*, Y.J. Kang*, “Environmental Aluminum Oxide Inducing Neurodegeneration in Human Neurovascular Unit with Immunity,” Scientific Reports, 2024, 14:744

Drug Effectiveness

Neuron-Glia Chip

  Assay


  • Microgliosis live cell imaging
  • Live cell assessment for phagocytosis
  • Neuroinflammation and neurodegeneration assessment
  • Amyloid beta or alpha synuclein production assessment

 Publication List


  1. J. Park, I. Wetzel, I. Marriott, D. Dréau, C. D’Avanzo, D.Y. Kim, R.E. Tanzi, H. Cho, “A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease,” Nature Neuroscience 2018, 21:941-951
  2. H. Chun, I. Marriott, C.J. Lee, H. Cho, “Elucidating the Interactive Roles of Glia in Alzheimer’s Disease Using Established and Newly Developed Experimental Models,” Frontiers in Neurology 2018, 9:797
  3. A. McQuade, Y.J. Kang, J. Hasselmann, A. Jairaman, A. Sotelo, S.K. Shabestari, M. Coburn, J.P. Chadarevian, G. Fote, C.H. Tu, E. Danhash, J. Silva, E. Martinez, C. Cotman, G.A. Prieto, L.M. Thompson, J.S. Steffan, I. Smith, H. Davtyan, M. Cahalan, H. Cho, M. Blurton-Jones, “Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease,” Nature Communications 2020, 11:5320

  4. H. Chun, H. Im, Y.J. Kang, Y. Kim, J.H. Shin, W. Won, J. Lim, Y. Ju, Y.M. Park, S. Kim, S.E. Lee, J. Lee, J. Woo, Y. Hwang, H. Cho, S. Jo, J.-H. Park, D. Kim, D.Y. Kim, J.-S. Seo, B.J. Gwag, Y.S. Kim, K.D. Park, B.-K. Kaang, H. Cho, H. Ryu*, C.J. Lee*, “Severe reactive astrocytes precipitate the hallmarks of Alzheimer’s disease via H2O2,” Nature Neuroscience 2020, 23:9

  5. Y.J. Kang, H.-Y. Tan, C.Y. Lee, H. Cho “An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models,” Advanced Science 2021, 8:2101251 (frontispiece cover imaged)

  6. V.A. Jairaman, A. McQuade, A. Granzotto, Y.J. Kang, J.P. Chadarevian, S. Gandhi, I. Parker, I. Smith, H. Cho, S.L. Sensi, S. Othy, M. Blurton-Jones, M.D. Cahalan “TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia,” eLife 2022, 11:e73021

  7. Y.J. Kang, Y.N. Diep, M. Tran, V.T.A Tran, G. Ambrin, H. Ngo, H. Cho*, “Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration,” Nature Protocols 2023, 18:9 (cover imaged)

  8. Y.J. Kang, S.J. Hyeon, A. McQuade, J. Lim, S.H. Baek, Y.N. Diep, K.V. Do, Y Jeon, D.-G. Jo, C.J. Lee, M. Blurton-Jones, H. Ryu, H. Cho, “Neurotoxic microglial activation via IFNγ-induced Nrf2 reduction exacerbating Alzheimer’s disease,” Advanced Sciences, 2024, 12:2304357

  9. J.-C. Park, J.W. Han, W. Lee, J. Kim, S.-E. Lee, D. Lee, H. Choi, J. Han, Y.J. Kang, Y.N. Diep, H. Cho, J.-I. Kim, I. Mook-Jung, “Microglia gravitate toward amyloid plaques surrounded by externalized phosphatidylserine via TREM2,” Advanced Science, 2024, 11:2400064

  10. X. Zhu, Y.N. Diep, V.T.A. Tran, Y.J. Kang, L.P. Lee, H. Cho, “Piezo1 activation promotes glial anti-inflammation and tau dephosphorylation in an Alzheimer’s disease model,” BioChip 2025, 19: https://doi.org/10.1007/s13206 025-00228-9

Neuronal Circuitory Chip

  Assay


  • Neuron-Neuron interaction
  • Taupropagation

 Publication List


  1. S. Takedaa, S. Wegmanna, H. Cho, S.L. DeVosa, C. Comminsa, A.D. Roea, S.B. Nichollsa, G.A. Carlsonc, R. Pitstickc, C.K. Nobuharaa, I. Costantinoa, M.P. Froscha, D.J. Müllerd, D. Irimiab, B.T. Hyman, “Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau species derived from tau-transgenic mouse and human Alzheimer's disease brain,” Nature Communications 2015, 6:4890

Multi-Organ Axis

Gut-Brain-Vascular Axis

  Assay


  • Gut-Vascular-Brain interaction
  • Drug effect in gut metabolites
  • Drug penetration with gut-brain axis

 Publication List


  1. (Under Review)